CA125 is a repeating peptide epitope of the mucin MUC16, which promotes cancer cell proliferation and inhibits anti-cancer immune responses. CA125 has been extensively studied as a biomarker in three distinct clinical scenarios: (1) as a screening test for early detection of ovarian cancer, (2) to differentiate between benign and malignant diseases in pre- and post-menopausal women with pelvic masses, and (3) to track the response to therapy in women with ovarian cancer.
Specifications
Catalog Number:
KB-1272
Antibodies Name:
REGN5688-MUC16-hIgG4m01
Host Cell Line:
EXPI-CHO
Target:
MUC16
Species Reactivity:
Human
Application:
ELISA
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA
Characterization
Application
References
1.?Rump A, Morikawa Y, Tanaka M, Minami S, Umesaki N, Takeuchi M, Miyajima A. Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. J Biol Chem. 2004;279:9190ÿ9198.
