Kinase Cell Line Overview

Kinases play crucial roles in various complex cellular pathways, including cell metabolism, cell signaling, and cell transport, making them vital to human physiology. Loss-of-function or gain-of-function mutations in kinases can lead to various types of cancer and human immune, neurological, and infectious diseases. Due to their significant cellular functions, kinases have emerged as important drug targets in drug discovery and development, particularly in the treatment of diverse cancers.

Ba/F3, a murine pro-B cell line, grows and proliferates in vitro depending on the presence of IL-3 in the medium. However, Ba/F3 cells can also proliferate without IL-3 due to the overexpression of specific kinases, which act as driver genes for Ba/F3 proliferation and can be used to assess the targeted inhibition of specific kinases by small molecule drugs.

Kyinno offers more than 850 Ba/F3 or human kinase cell lines, encompassing various signaling pathways such as epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), erb-b2 receptor tyrosine kinase 2 (ERBB2), platelet-derived growth factor receptor (PDGFR), Kit, ABL, AKT1, TPR, MPL, RAS, and more. We also provide a range of kinase cell lines that stably express a variety of fluorescent proteins or luciferase, providing scientists with customizable options for their research needs. We have rigorously verified the stability, accuracy, and functional effectiveness of these cell lines to meet our clients’ requirements for direct application in the study of signaling pathways, drug screening, and in vivo imaging.

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