PBMC Humanized Mouse Model
In Vivo Services
PBMC Humanized Mouse Model Overview
PBMC humanized mice serve as an effective model for tumor immunology research. T cells within human PBMCs proliferate in response to stimulation by mouse xenogeneic antigens, while other cell types maintain low levels or undergo premature cell death. The predominant human cells in PBMC humanized mice are T cells, making them suitable for various studies requiring T cell immune responses.
KYINNO has established a stable PBMC humanization model and screened a library of PBMC donors. These selected donors exhibit stable humanization levels, exhibit mild GVHD symptoms, and provide a drug administration window of approximately 6 weeks. These characteristics render them suitable for evaluating the efficacy of various antibody drugs targeting T cells.
All in vivo Services
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