Gene Editing Cell Line

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Gene Editing Cell Line Overview

Since the emergence of CRISPR gene editing technology in 2012, it has become the preferred choice of scientists worldwide due to its simplicity, specificity, and high efficiency. In 2020, researchers working on the CRISPR system were awarded the Nobel Prize in Chemistry. CRISPR gene editing technology has been utilized to explore biological functions, analyze gene information, and provide strategic support for humanity in the fight against diseases and in the design of crops. It also enables the development of gene-edited animal cell lines for studying gene function, disease mechanisms, and potential therapeutic targets. It has also facilitated the development of advanced research models, including engineered cell systems such as the HEK293-ERBB2 cell line, which are used to investigate gene function, signaling pathways, and therapeutic targets. In recent years, CRISPR technology has also undergone a series of improvements, including reduced off-target effects, increased editing sites, and more efficient delivery methods, which will have a lasting and profound impact on scientific research, agriculture, and the medical field, particularly in applications such as cell line construction for advanced functional studies.

Kyinno offers more than 200 various CRISPR gene-editing cell lines, encompassing knockout and knockin cells, along with customized services for researchers, including custom gene-edited cell line construction. Our gene-edited cell lines can be employed in the exploration of protein or RNA biological functions, drug screening, synthetic lethal research, and numerous other applications. Representative models include antigen-modified tumor variants such as the CT26-GPC3 cell line, developed to support target validation and immuno-oncology research. Additionally, we can employ pegRNA and prime editing, as well as lipid nano-particle (LNP) technology, to perform multi-site editing simultaneously, enhancing gene editing efficiency while minimizing off-target effects.

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