KB-1036

GK1.5-mIgG2a

Background

GK1.5 is a mIgG2a mAb that recognizes the mouse CD4 Ag. The CD4 antigen is a membrane glycoprotein that belongs to the immunoglobulin superfamily. It is found on the cell surface and has a molecular weight of 55 kDa. CD4 acts as a co-receptor, working together with the T cell receptor (TCR) to interact with class II MHC molecules presented by antigen presenting cells (APC). It is expressed on the majority of thymocytes, most helper T cells, a subset of NK-T cells, and to a lesser extent, on dendritic cells and macrophages. CD4 plays a crucial role in the development and optimal functioning of mature T cells.

Specifications

Catalog Number:
KB-1036
Cell Line Name:
GK1.5-mIgG2a
Price:
0
Host Cell Line:
EXPI-CHO
Target:
Mouse-CD4
Species Reactivity:
Mouse
Application:
ELISA
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA

References

1.Comparison of GK1.5 and chimeric rat/mouse GK1.5 anti-CD4 antibodies for prolongation of skin allograft survival and suppression of alloantibody production in mice
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