KB-1384

M6903-hIgG2

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Background

T cell immunoglobulin and mucin domain-3 (TIM-3) represents an imperative immune checkpoint pivotal in regulating standard immune responses, yet opportunistically exploited by tumor cells to elude immune surveillance. Predominantly found on immune cells, particularly on dysfunctional and depleted T cells, TIM-3's interaction with its ligands precipitates a suppression of T cell activity. Enter antagonistic ligand-blocking anti-TIM-3 antibodies, such as M6903, which harbor immense potential to counteract T cell inhibition, reignite antigen-specific T cell functionality, and bolster the immune system's anti-tumor efficacy. M6903 stands out as a fully human anti-TIM-3 antibody devoid of effector function but boasting exceptional affinity and specificity towards TIM-3. Notably, M6903's pivotal action lies in obstructing the binding of TIM-3 to three of its ligands¡ªphosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9).

Specifications

Catalog Number:
KB-1384
Cell Line Name:
M6903-hIgG2
Price:
0
Host Cell Line:
EXPI-CHO
Target:
TIM3
Species Reactivity:
Human
Application:
ELISA
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2¦Ìm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20¡ãC to -80¡ãC; Stored at 2-8¡ãC for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA

References

1. Lan Y, Zhang D, Xu C, Hance KW, Marelli B, Qi J, Yu H, Qin G, Sircar A, Hern¨¢ndez VM. Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-¦Â. Sci Transl Med. 2018;10(eaan5488). doi: 10.1126/scitranslmed.aan5488. 2. Sabatos-Peyton CA, Brannetti B, Harris AS, Huber T, Pietzonka T, Mataraza JM, Blattler WA, Hicklin DJ, Vasquez M, DeKruyff RH, et al. Antibody molecules to tim-3 and uses thereof. United States patent US2015/0218274 A1. 2015.
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