KB-1211

hu9B12-hIgG1

Home » Antibody » hu9B12-hIgG1

Background

Lymphocyte antigen 6E (LY6E), also referred to as RIG-E, SCA2, and TSA1, is a cell surface protein anchored by GPI. It plays a crucial role in regulating the proliferation, differentiation, and activation of T-lymphocytes. LY6E interacts with CD3Z/CD247, a component of the T-cell receptor (TCR) signaling pathway, at the plasma membrane, thereby modulating the phosphorylation of CD3Z/CD247. This interaction restricts the entry of various human coronaviruses, including SARS-CoV, MERS-CoV, and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Additionally, LY6E acts as the primary receptor for syncytin-A (SynA), contributing to the normal fusion of syncytiotrophoblast layer I (SynT-I) and the proper development of both fetal and maternal vasculatures within the placenta. It may also function as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.

Specifications

Catalog Number:
KB-1211
Cell Line Name:
hu9B12-hIgG1
Price:
0
Host Cell Line:
EXPI-CHO
Target:
LY6E
Species Reactivity:
Human
Application:
ELISA | FACS
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2¦Ìm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20¡ãC to -80¡ãC; Stored at 2-8¡ãC for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA | FACS

References

1. A novel thymocyte marker discriminating immature from mature thymocyte subsets. J Immunol. 1992. 2. Mao M, Yu M, Tong JH et al. RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the difffferentiation of acute promyelocytic leukemia cell. Proc Natl Acad Sci U S A. 1996.
Please enable JavaScript in your browser to complete this form.