293T-CLDN2 Cell Line

CLDN2 (Claudin 2) is a Protein Coding gene. This gene encodes a member of the claudin family, a group of integral membrane proteins that constitute the backbone of tight junction strands. Members of this family share a common structure with four transmembrane domains, two extracellular loops, and cytoplasmic N- and C-termini. Claudins function primarily in regulating paracellular permeability, which governs the selective passage of ions and small molecules across epithelial and endothelial sheets. The encoded protein, claudin-2, is predominantly expressed in leaky epithelia including the proximal tubules of the kidney, the small intestine, and the liver. It functions as a cation-selective paracellular channel that mediates pore pathway permeability, specifically facilitating the paracellular transport of sodium, potassium, and water. CLDN2 expression is dynamically regulated during development and disease, and its upregulation has been implicated in the pathogenesis of colorectal cancer, where it promotes cell proliferation and migration. Mutations in this gene or alterations in its expression have also been linked to chronic inflammatory conditions such as inflammatory bowel disease.