KB-1212

RG6102-TFRC-hIgG1

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Background

RG6102 is a bispecific 2+1 monoclonal antibody (mAb) under development for the treatment of Alz-heimer disease (AD). It combines the anti-amyloid beta antibody gantenerumab with a transferrin receptor 1-binding ¡°Brain Shuttle¡±module, enabling active receptor-mediated transport across the blood-brain barrier.

Specifications

Catalog Number:
KB-1212
Cell Line Name:
RG6102-TFRC-hIgG1
Price:
0
Host Cell Line:
EXPI-CHO
Target:
TFRC
Species Reactivity:
Human
Application:
FACS
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2¦Ìm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20¡ãC to -80¡ãC; Stored at 2-8¡ãC for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | FACS

References

1.Model-informed development of RG6102, an amyloid-targeting investigational drug with enhanced brain penetration properties.
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