Combination study in cells
Considering cancer signaling complexity, combination treatment is aimed to increase efficacy, decrease dosage, and/or slow down the development of drug resistance. We typically test two compounds at 1:1 constant ratio or 6X6 matrix diagonal combination studies. CalcuSyn 2.0 software is used for data analysis.
1:1 Constant Ratio Combination
6X6 Diagonal Constant Ratio Combination (Example II)
Single dose fixed combination (example III), If IC50 of the one cpmd cannot be fitted out