KB-1204

VSTB112-hIgG1

Background

VSTB112-hlgG1, a high affinity-specific humanized hlgG1 antibody against VISTA.VISTA(V-domain immunoglobulin suppressor of T cell activation)has become a current focus of research.VISTA not only acts as a ligand expressed on antigenpresenting cells, but also functions as a receptor on T cells.VISTA was identified as a V-set receptor that suppresses T cell-associated response for immune evasion and survival in several human cancers, such as prostate cancer, non-small cell lung cancer (NSCLC), and colorectal carcinoma.

Specifications

Catalog Number:
KB-1204
Cell Line Name:
VSTB112-hIgG1
Price:
0
Host Cell Line:
EXPI-CHO
Target:
VISTA
Species Reactivity:
Human
Application:
FACS
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | FACS

References

1.Huang Xing,Zhang Xiaozhen,Li Enliang et al. VISTA: an immune regulatory protein checking tumor and immune cells in cancer immunotherapy.[J] .J Hematol Oncol, 2020, 13: 83. 2.Villarroel-Espindola F, et al. Spatially resolved and quantitative analysis of VISTA/PD-1H as a novel immunotherapy target in human non-small cell lung cancer. Clin Cancer Res. 2018;24(7):1562-73.
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