KB-1065-01

Tiragolumab

Background

TIGIT is a novel inhibitory immune checkpoint that is present on activated T cells and natural killer cells in multiple cancers. TIGIT expression has been linked with PD-1, particularly in tumor-infiltrating T cells. Tiragolumab is a fully human IgG1/kappa anti-TIGIT monoclonal antibody with an intact Fc region that blocks the binding of TIGIT to its receptor PVR. Investigators hypothesized that anti-TIGIT antibodies, such as tiragolumab, can restore antitumor response and potentially strengthen the activity of anti–PD-L1/PD-1 antibodies.

Specifications

Catalog Number:
KB-1065-01
Cell Line Name:
Tiragolumab
Price:
0
Host Cell Line:
EXPI-CHO
Target:
TIGIT
Species Reactivity:
Human
Application:
ELISA | FACS | FACS Blocking | KD | ADCC assay
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA | FACS | FACS Blocking | KD | ADCC assay

References

1.Wang J. Final progression-free survival, interim overall survival, and biomarker analyses of CHOICE-01: A phase III study of toripalimab versus placebo in combination with first-line chemotherapy for advanced NSCLC without EGFR/ALK mutations. Presented at: 2022 ASCO Annual Meeting; June 3-7, 2022; Chicago, IL. Abstract 362936. 2.Coherus and Junshi Biosciences receive complete response Letter from US FDA for toripalimab BLA. News release. May 2, 2022. Accessed June 9, 2022. https://bit.ly/3ORWbun
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