KB-1145

SAR442257-CD28-hIgG4-S228P

Background

SAR442257 (CD38/CD28xCD3) is a trispecific T cell engager designed for the treatment of multiple myeloma (MM). Its cytotoxic activity and anti-tumor efficacy is dependent on the expression of CD38 by malignant plasma cells and the recruitment and activation of T cells via CD3 and CD28.

Specifications

Catalog Number:
KB-1145
Cell Line Name:
SAR442257-CD28-hIgG4-S228P
Price:
0
Host Cell Line:
EXPI-CHO
Target:
CD28
Species Reactivity:
Human
Application:
ELISA | FACS
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA | FACS

References

1.Edmead CE, Lamb JR, Hoyne GF. The T cell surface protein, CD28. Int J Biochem Cell Biol. 1997 Aug-Sep;29(8-9):1053-7. 2.Ma BY, Mikolajczak SA, Yoshida T, Yoshida R, Kelvin DJ, Ochi A. CD28 T cell costimulatory receptor function is negatively regulated by N-linked carbohydrates. Biochem Biophys Res Commun. 2004 Apr 23;317(1):60-7.
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