KB-1229

Nelistotug

Background

Immune checkpoint blockade has become a promising therapeutic approach to reverse immune cell exhaustion. Coinhibitory CD96 and T-cell immunoglobulin and ITIM domain (TIGIT), together with costimulatory CD226, bind to common ligand CD155. The balancing between three receptors fine-tunes immune responses against tumors. High levels of TGF-β1 in HCC patients up-regulated CD96 expression and dynamically changed the balance between CD96, TIGIT and CD226 in NK cells. Nelistotug antibody can block CD96-CD155 interaction, restore NK cell immunity to tumor by reversing NK cell exhaustion, and promote anti-tumor response of CD8+ TIL.

Specifications

Catalog Number:
KB-1229
Cell Line Name:
Nelistotug
Price:
0
Host Cell Line:
EXPI-CHO
Target:
CD96
Species Reactivity:
Human
Application:
ELISA
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA

References

1.Yumeng Wang , Congwen Wang , Junjun Qiu , Xinyu Qu , Jing Peng , Chong Lu , Meng Zhang , Mingxing Zhang , Xingling Qi , Guiling Li , Keqin Hua . Targeting CD96 overcomes PD-1 blockade resistance by enhancing CD8+ TIL function in cervical cancer. Immunother Cancer. 2022 Mar;10(3):e003667. 2.Haoyu Sun , Qiang Huang , Mei Huang , Hao Wen , Renyong Lin , Meijuan Zheng , Kun Qu , Kun Li , Haiming Wei , Weihua Xiao , Rui Sun , Zhigang Tian , Cheng Sun. Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma. Hepatology.2019 Jul;70(1):168-183.
Please enable JavaScript in your browser to complete this form.