KB-1181

MOR07692-hIgG1

Background

MST1R (Macrophage-stimulating protein receptor), is a receptor tyrosine kinase belonging to the tumor necrosis factor receptor family. Overactivation of MST1R in cancer is associated with tumorigenesis, progression, and metastasis. Studies have shown that MST1R is highly expressed in various tumors, including lung cancer, breast cancer, gastric cancer, colorectal cancer, and others. Therefore, MST1R has emerged as a potential target for cancer therapy. Researchers are actively developing MST1R inhibitors to suppress its activity, thereby interfering with processes such as tumor cell proliferation, migration, and invasion.

Specifications

Catalog Number:
KB-1181
Cell Line Name:
MOR07692-hIgG1
Price:
0
Host Cell Line:
EXPI-CHO
Target:
MST1R
Species Reactivity:
Human
Application:
FACS
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | FACS

References

1.Catenacci D V T , Cervantes G , Yala S ,et al.RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma[J].Cancer Biology & Therapy, 2011, 12(1):9-46. 2.Catenacci D V T , Henderson L , Cervantes G ,et al.Abstract LB-124: RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma[J].Cancer Research, 2011, 71(8 Supplement):9-46.
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