KB-1125

JNJ372-EGFR-hIgG1

Background

JNJ372-EGFR-hlgG1, a high affinity-specific humanized IgG1 antibody against EGFR.The Epidermal Growth Factor Receptor (EGFR) is frequently expressed at elevated levels in different forms of cancer and expression often correlates positively with cancer progression and poor prognosis. EGFR is responsible for the maintenance and functions of cancer stem cells (CSCs), including stemness, metabolism, immunomodulatory-activity, dormancy and therapy-resistance. In a variety of cancer cells, scientists have found high expression of EGFR.

Specifications

Catalog Number:
KB-1125
Cell Line Name:
JNJ372-EGFR-hIgG1
Price:
0
Host Cell Line:
EXPI-CHO
Target:
EGFR
Species Reactivity:
Human
Application:
ELISA | FACS | FACS Blocking | KD
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA | FACS | FACS Blocking | KD

References

1.Talukdar Sarmistha,Emdad Luni,Das Swadesh K et al. EGFR: An essential receptor tyrosine kinase-regulator of cancer stem cells.[J] .Adv Cancer Res, 2020, 147: 161-188.
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