KB-1289

B09-57-hIgG1

Background

Hepatocyte growth factor receptor (HGFR), also known as Met, encodes a heterodimeric (alpha, beta) tyrosine kinase receptor. Activation of the signaling cascade occurs when c-MET binds to its ligand, hepatocyte growth factor (HGF). The c-MET/HGF signaling pathway is involved in multiple key biological processes, including the ability of cells to proliferate and migrate, angiogenesis, and the epithelium-mesenchyme transition. In CRC, as in other types of neoplasms, abnormal expression of c-MET has been associated with tumors with high cell proliferation rate, cell dissociation, tumor aggressiveness, invasiveness and, ultimately, worse prognosis.

Specifications

Catalog Number:
KB-1289
Cell Line Name:
B09-57-hIgG1
Price:
0
Host Cell Line:
EXPI-CHO
Target:
MET
Species Reactivity:
Human
Application:
ELISA
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA

References

1.Engineering, Characterization, and Biological Evaluation of an Antibody Targeting the HGF Receptor
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