KB-1188

APL1020-001-hIgG1

Background

The coinhibitory molecule B7-H4, an important member of the B7 family, is abnormally expressed in tumors, inflammation and autoimmune diseases. B7-H4 negatively regulates T cell immune response and promotes immune escape by inhibiting the proliferation, cytokine secretion, and cell cycle of T cells. Moreover, B7-H4 plays an extremely important role in tumorigenesis and tumor development including cell proliferation, invasion, metastasis, anti-apoptosis, etc.

Specifications

Catalog Number:
KB-1188
Cell Line Name:
APL1020-001-hIgG1
Price:
0
Host Cell Line:
EXPI-CHO
Target:
B7H4
Species Reactivity:
Human
Application:
ELISA | FACS | KD
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA | FACS | KD

References

1.Y. Kamimura et al. Possible involvement of soluble B7–H4 in T cell-mediated inflammatory immune responses. Biochem. Biophys. Res. Commun.(2009) 2.D. Darmochwal-Kolarz et al. The expression of B7–H1 and B7–H4 co-stimulatory molecules on myeloid and plasmacytoid dendritic cells in pre-eclampsia and normal pregnancy. J. Reprod. Immunol.(2013)
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