KB-1275

AMG305-CDH3-hIgG1

Background

AMG 305 is a pioneering BiTE® (bispecific T cell engager) molecule that simultaneously binds to both P-cadherin (CDH3) and mesothelin (MSLN) to exert potent cytotoxic effects. Immunohistochemistry analysis reveals that CDH3 and MSLN are co-expressed in various types of solid tumors. However, in normal tissues, immunostaining demonstrates a lower occurrence of overlapping co-expression compared to the expression of either one of the targets alone. AMG 305 employs an avidity-based mechanism to activate T cells, enabling them to selectively eliminate CDH3+MSLN+ tumor cells while displaying limited activity against normal cells expressing only one of the target antigens.

Specifications

Catalog Number:
KB-1275
Cell Line Name:
AMG305-CDH3-hIgG1
Price:
0
Host Cell Line:
EXPI-CHO
Target:
CDH3
Species Reactivity:
Human
Application:
FACS
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | FACS

References

1.AMG 305, a dual targeting BiTE®molecule with selective activity for solid tumors that co-express CDH3 and MSLN
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