KB-1151

9D8-hIgG1

Background

Fibrinogen-like protein 2 (FGL2) is a membrane-bound or secreted protein expressed by macrophages, T cells, and tumor cells that has coagulation activity or immune-suppressive functions. FGL2 promotes mammary tumor progression by promoting tumor angiogenesis or inducing epithelial-to-mesenchymal transition. 9D8-hlgG1 is a monoclonal antibody that only binds FGL2.

Specifications

Catalog Number:
KB-1151
Cell Line Name:
9D8-hIgG1
Price:
0
Host Cell Line:
EXPI-CHO
Target:
FGL2
Species Reactivity:
Human
Application:
ELISA
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA

References

1.Marazzi, S. et al. Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. J. Immunol. 161, 138–147 (1998). 2.McGilvray, I. D. et al. Murine hepatitis virus strain 3 induces the macrophage prothrombinase fgl-2 through p38 mitogen-activated protein kinase activation. J. Biol. Chem. 273, 32222–32229 (1999).
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