KB-1235

GEN1042-CD137-hIgG1

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Background

4-1BB (CD137) is a costimulatory TNFR expressed on immune cells, including T cells, natural killer cells and monocytes. While na?ve T cells lack 4-1BB expression, the receptor is upregulated on T-cell receptor engagement. Crosslinking of 4-1BB activates the MAPK and NF-¦ÊB signaling pathways and enhances T-cell proliferation and cytokine production, enhances cytotoxic T-cell effector functions and prevents activation-induced cell death of T cells. GEN1042 (DuoBody?-CD40x4-1BB) is an investigational, novel, agonistic, bispecific antibody that combines targeting and conditional activation of CD40 and 4-1BB on immune cells for priming and (re-) activation of tumor-specific immune responses. GEN1042-CD137-hIgG1 is a monoclonal antibody that only targets CD137.

Specifications

Catalog Number:
KB-1235
Cell Line Name:
GEN1042-CD137-hIgG1
Price:
0
Host Cell Line:
EXPI-CHO
Target:
CD137
Species Reactivity:
Human
Application:
ELISA
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2¦Ìm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20¡ãC to -80¡ãC; Stored at 2-8¡ãC for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA

References

1.DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity 2.Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future strategies
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