KB-1396

HFB-200301-hIgG1

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Background

TNFR2, belonging to the TNFR family of costimulatory molecules, presents an appealing target for T-cell co-stimulation due to its expression on tumor-infiltrating lymphocytes across a diverse spectrum of tumors. HFB200301, a pioneering agonistic anti-TNFR2 antibody, exhibits potent and selective binding to TNFR2, prompting the activation of CD4 T cells, CD8 T cells, and NK cells. Distinguished by its unique mechanism of action, HFB200301 relies predominantly on its agonistic activity across various effector cell types within the tumor microenvironment. We anticipate that this novel approach will yield benefits for a patient population identified by a distinctive biomarker signature.

Specifications

Catalog Number:
KB-1396
Cell Line Name:
HFB-200301-hIgG1
Price:
0
Host Cell Line:
EXPI-CHO
Target:
TNFR2
Species Reactivity:
Human
Application:
ELISA
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2¦Ìm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20¡ãC to -80¡ãC; Stored at 2-8¡ãC for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA

References

1.Rauert H, Wicovsky A, Muller N, Siegmund D, Spindler V, Waschke J, et al.. Membrane Tumor Necrosis Factor (TNF) Induces P100 Processing via TNF Receptor-2 (TNFR2). J Biol Chem (2010) 285:7394¨C404. 2.Shamdani S, Uzan G, Naserian S. TNFalpha-TNFR2 Signaling Pathway in Control of the Neural Stem/Progenitor Cell Immunosuppressive Effect: Different Experimental Approaches to Assess This Hypothetical Mechanism Behind Their Immunological Function. Stem Cell Res Ther (2020) 11:307.
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