KB-1286

5G12-hIgG1-Siglec15

Home » Antibody » 5G12-hIgG1-Siglec15

Background

Siglec-15, a member of sialic acid-binding immune-globulintype lectins, is a highly conserved Type I cell surface protein, which was previously reported to play a role in osteoclast differentiation and bone remodeling1,2. Siglec-15 is consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 can recognize sialylated glycans and regulate osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Specifications

Catalog Number:
KB-1286
Cell Line Name:
5G12-hIgG1-Siglec15
Price:
0
Host Cell Line:
EXPI-CHO
Target:
Siglec15
Species Reactivity:
Human
Application:
ELISA | FACS
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2¦Ìm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20¡ãC to -80¡ãC; Stored at 2-8¡ãC for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA | FACS

References

1.Angata T, Tabuchi Y, Nakamura K, Nakamura M. Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. Glycobiology. 2007;17(8):838¨C46. 2.Ishida-Kitagawa N, Tanaka K, Bao X, Kimura T, Miura T, Kitaoka Y, et al. Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12). J Biol Chem. 2012;287(21):17493¨C502.
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