[gtranslate]
[gtranslate]

KB-1084

2M24-hIgG1

Background

Dectin-1 belongs to the hemITAM family and can be found in the plasma membrane of various myeloid cells, including DCs, monocytes, and macrophages, as well as B cells. Activation of dectin-1 by fungal cell wallβ-glucans stimulates phagocytosis, the production of ROS, and NFkB-mediated cytokine secretion. In contrast to the TLR pathways, dectin-1-mediated NFkB signaling is driven by Syk recruitment and the subsequent formation of a multiprotein signaling complex, the CARD9 signalosome.

Specifications

Catalog Number:
KB-1084
Antibodies Name:
2M24-hIgG1
Host Cell Line:
EXPI-CHO
Target:
Dectin-1
Species Reactivity:
Human
Application:
ELISA | FACS
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA | FACS

Characterization

Application

References​

1.Netea MG, Dom³ànguez-Andr¹Ès J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, et al. Defining Trained Immunity and its Role in Health and Disease. Nat Rev Immunol (2020) 20:375ÿ88. 2.Sancho D, Reis e Sousa C. Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis. Annu Rev Immunol (2012) 30:491ÿ529.
Please enable JavaScript in your browser to complete this form.