KB-1161

1G4V1-hIgG1

Background

The lymphocyte antigen 6 complex locus G6D (LY6G6D) is a member of the lymphocyte antigen 6 superfamily (Ly-6SF). LY6G6D is positioned within the MHC class III region on chromosome 6, wherein it encodes a polypeptide comprising 133 amino acid residues with an approximate molecular weight of 13.7 kDa. Genentech, an innovative leader in large molecule pharmaceuticals, has developed a anti-LY6G6D/CD3 bispecific antibody (LY6G6D-TDB) for colorectal cancer (CRC) treatment in its earlier days. In mouse xenograft tumor models, LY6G6D-TDB shows anti-tumor efficacy as a single agent against established colorectal tumors. 1G4V1-hIgG1 is a monoclonal antibody that only binds to LY6G6D.

Specifications

Catalog Number:
KB-1161
Cell Line Name:
1G4V1-hIgG1
Price:
0
Host Cell Line:
EXPI-CHO
Target:
LY6G6D
Species Reactivity:
Human
Application:
ELISA
Purification Method:
Affinity purified
Concentration:
>2mg/mL
Purity:
>95% by SDS-PAGE and SEC-HPLC
Endotoxin Level:
<0.5 EU/mg as determined by the LAL method
Sterility:
0.2μm filtered
Formulation:
20mM sodium citrate,150mM NaCl, pH5.5
Storage:
Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.
Bio Safety Level:
1
Validation:
SDS-PAGE | SEC-HPLC | ELISA

References

1.Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer
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