Antibody discovery

In KYinno, more than 50 scientists are dedicated to offer a comprehensive and integrated antibody solution, including target discovery and validation, antigen design and preparation, Hybridoma/Phage display/Single B cell, high throughput antibody screening, functional validation, humanization and recombinant expression. With our unique technologies, antibodies for many hard targets, such as GPCR and Ion channel, have been successfully generated.

Phage display

The synthetic Human Fab library comprise 30 sub-libraries and total capacity is 3.4 x 10¹⁰. The library was designed according to human Ig VH/VL database for higher druggability. This library has successfully delivered high affinity binders for more than 50 projects, with KD up to 10^-10M.

Example:

An example of a binder specific to human NKG2D obtained from the library: