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CDX Model

CDX Model

Description:CDXModel 资料占位
Description:CDXModel 资料占位
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CDX

 

A cell line-derived xenograft or CDX model is one of the most widely used models for the study of anti-cancer therapies. It involves culturing human tumour cell lines and transplanting them into immunosuppressed mice or culturing mouse cell lines and transplanting them into immune-competent mice to study a compound’s effect on tumor growth in vivo. 

 

KYinno has developed over 300 engineered BaF3 cell lines by introducing overexpression or mutation of various kinases. We also created a panel of isogenic cancer cell lines with site-specific mutations introduced through CRISPR gene-editing technologies. All these engineered cell lines have been well validated for in vivo efficacy studies to support both small molecule and biologics drug discovery programs. 

 

Case studies:

BaF3: RET inhibitor treatment in engineered BaF3-RET tumour model            

 

 

MC38: PD-L1 antibody treatment in MC38 syngeneic tumour model

 

 

 

 

 

KYinno

 KYinno Biotechnology Co., Ltd

Cell phone No: +(86)10-58222701 / 58222702

Room 609, No.3 Building, Yizhuang Biomedical Park, No.88, Kechuang Six Street, BDA,

 

Beijing, China, 101111

Email: bd@kyinno.com 

KYinno   京ICP备17041979号    www.300.cn