CDX

A cell line-derived xenograft or CDX model is one of the most widely used models for the study of anti-cancer therapies. It involves culturing human tumour cell lines and transplanting them into immunosuppressed mice or culturing mouse cell lines and transplanting them into immune-competent mice to study a compound’s effect on tumor growth in vivo. 

KYinno has developed over 300 engineered BaF3 cell lines by introducing overexpression or mutation of various kinases. We also created a panel of isogenic cancer cell lines with site-specific mutations introduced through CRISPR gene-editing technologies. All these engineered cell lines have been well validated for in vivo efficacy studies to support both small molecule and biologics drug discovery programs. 

Case studies:

BaF3: RET inhibitor treatment in engineered BaF3-RET tumour model            

MC38: PD-L1 antibody treatment in MC38 syngeneic tumour model