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PROteolysis TArgeting Chimera (PROTAC) screening platform

PROteolysis TArgeting Chimera (PROTAC) screening platform

Description:
Description:
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PROteolysis TArgeting Chimera (PROTAC) is a chemical knockdown strategy targeting cellular proteins for degradation through the ubiquitin-proteasome system. PROTACs are heterobifunctional small molecules with three chemical elements: a ligand binding to a target protein, a ligand binding to the E3 ubiquitin ligase, and a linker for conjugating these two ligands. PROTACs have become a promising and appealing technology for modulating a protein of interest (POI) by degradation and   attracted great attention both from academia and industry. 

 

Assay Specifications:  

The target proteins are tagged with HIBIT in various cell lines through gene-editing techniques and the degree of target protein degradation is well validated. Assays are performed using a 96-well format. Each data point is tested in triplicate, and appropriate assay controls are included. 

 

Case study:

Miacapa2-hibit-RAS

 

Turn-Around Time:

2 - 3 weeks

Timeline & pricing may vary depending on custom assay specifications.

KYinno

 KYinno Biotechnology Co., Ltd

Cell phone No: +(86)10-58222701 / 58222702

Room 609, No.3 Building, Yizhuang Biomedical Park, No.88, Kechuang Six Street, BDA,

 

Beijing, China, 101111

Email: bd@kyinno.com 

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