In vitro Assay
PROteolysis TArgeting Chimera (PROTAC) screening platform
- Categories:In Vitro Assay
- Time of issue:2020-12-23 11:05:09
PROteolysis TArgeting Chimera (PROTAC) is a chemical knockdown strategy targeting cellular proteins for degradation through the ubiquitin-proteasome system. PROTACs are heterobifunctional small molecules with three chemical elements: a ligand binding to a target protein, a ligand binding to the E3 ubiquitin ligase, and a linker for conjugating these two ligands. PROTACs have become a promising and appealing technology for modulating a protein of interest (POI) by degradation and attracted great attention both from academia and industry.
The target proteins are tagged with HIBIT in various cell lines through gene-editing techniques and the degree of target protein degradation is well validated. Assays are performed using a 96-well format. Each data point is tested in triplicate, and appropriate assay controls are included.
2 - 3 weeks
Timeline & pricing may vary depending on custom assay specifications.
KYinno Biotechnology Co., Ltd
Cell phone No: +(86)10-58222701 / 58222702
Room 609, No.3 Building, Yizhuang Biomedical Park, No.88, Kechuang Six Street, BDA,
Beijing, China, 101111